Recombinant tumor necrosis factor for superficial bladder tumors

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Cures and partial regression of murine and human tumors by recombinant human tumor necrosis factor.

We tested the effect of recombinant human tumor necrosis factor (TNF) on the growth of the murine methylcholanthrene induced fibrosarcoma and the human ovarian carcinoma (NIH:OVCAR-3) in mice. The mice received multiple doses (25-250 micrograms/kg) of TNF starting 7-10 days after s.c. transplantation of tumors when they were easily palpable. TNF was administered i.v. every other day for a total...

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Endoscopic Ultrasonic Aspiration of Superficial Bladder Tumors

The gold standard of surgical treatment for superficial bladder tumor is transurethral resection (TUR). However, the procedure has drawbacks: it needs skill to avoid perforation of the bladder wall, while burns on the resected tissue are disadvantageous for histological examination. We developed an endoscopic ultrasonic aspiration system which is easy to manipulate and makes no burns on aspirat...

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Immunomodulatory properties of recombinant murine and human tumor necrosis factor.

Tumor necrosis factor has traditionally been thought to have direct cytostatic and cytotoxic properties with little or no direct immunomodulatory activity. We report here that tumor necrosis factor is able to activate macrophages both in vitro and in vivo and can increase a mixed lymphocyte response and act as an adjuvant for both T- and B-cells in vivo. Adjuvant activity in T-cells occurred in...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 1992

ISSN: 0923-7534

DOI: 10.1093/oxfordjournals.annonc.a058331