Recombinant tumor necrosis factor for superficial bladder tumors
نویسندگان
چکیده
منابع مشابه
Cures and partial regression of murine and human tumors by recombinant human tumor necrosis factor.
We tested the effect of recombinant human tumor necrosis factor (TNF) on the growth of the murine methylcholanthrene induced fibrosarcoma and the human ovarian carcinoma (NIH:OVCAR-3) in mice. The mice received multiple doses (25-250 micrograms/kg) of TNF starting 7-10 days after s.c. transplantation of tumors when they were easily palpable. TNF was administered i.v. every other day for a total...
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The gold standard of surgical treatment for superficial bladder tumor is transurethral resection (TUR). However, the procedure has drawbacks: it needs skill to avoid perforation of the bladder wall, while burns on the resected tissue are disadvantageous for histological examination. We developed an endoscopic ultrasonic aspiration system which is easy to manipulate and makes no burns on aspirat...
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Treatment of rats with either intermittent bolus i.v. injections or continuous i.v. infusions of the same sublethal daily dose of tumor necrosis factor (TNF) results in decreased food intake and decreased nitrogen balance compared to saline-treated control rats. After 4 days of treatment, rats treated with intermittent bolus doses of TNF develop tolerance to the nutritional effects and consume ...
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Tumor necrosis factor has traditionally been thought to have direct cytostatic and cytotoxic properties with little or no direct immunomodulatory activity. We report here that tumor necrosis factor is able to activate macrophages both in vitro and in vivo and can increase a mixed lymphocyte response and act as an adjuvant for both T- and B-cells in vivo. Adjuvant activity in T-cells occurred in...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1992
ISSN: 0923-7534
DOI: 10.1093/oxfordjournals.annonc.a058331